George Barksdale, a wealthy Charleston planter and former member of the South Carolina House of Representatives, would be proud and extremely happy if he were alive today to see Twenty-seven George Street Built in 1778, just one year prior to the Revolutionary Wars shifting into South Carolina, Twenty-seven George street served as the townhouse for the Barksdale family when they were not at their country residence, Youghall Plantation. The Barksdale family was very active in the thriving city life of Charleston. George Barksdale served a term in office as a tax inquirer and collector for his home parish, as well as a trustee of the Independent Church or Christ Church.

In May of 1817, George's nephew and then owner, Thomas Barksdale, sold the townhouse. From that time on the house had numerous owners and occupants. The 1980s found the house unoccupied and in a state of disrepair until its meticulous restoration in 1985. Now it is Charleston's most elegant yet intimate inn.